Always keep both pages of layout open in front of you, left and right.
The reason for this is that when the readers opens the newspaper or magazine they first look at both pages. First from left to right and almost in a straight line across the middle of the pages. When reader is done with this (it will take a few seconds), usually he begin to read the left side.
Make sure that you avoid same level of headlines on a left and right. Because it will look like this headlines are connected and continue on each other, also avoid images of similar size and close one to another.
If it is featured on one page vertical photo, on the other page photo should be horizontal and so on. The contrast between pages through a newspaper is important for design.
In addition to hard news announced on the front page, be sure to put few headlines that are “easier”, more fun.